Midway by way of his career, Cees Dekker reinvented himself. Soon after years of hardcore physics, he shifted his emphasis to ‘nanobiology’ at the switch of the millennium. A phrase he coined himself, to be a make a difference of point.

1996, 1st mesoscopic demand density waves devices; and 1st electrical measurements on only one metal nanocluster involving nanoelectrodes

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Non-equilibrium folding of particular person DNA molecules recaptured as many as a thousand situations inside of a strong condition nanopore

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Experimental phase diagram of negatively supercoiled DNA calculated by magnetic tweezers and fluorescence,

Due to the fact 2000 he moved to solitary-molecule biophysics and nanobiology, with study from DNA supercoiling studies of nucleosomes and DNA maintenance proteins to DNA translocation by way of nanopores. Not too long ago his study has centered on learning mobile division with micro organism on chip, although his ultimate fascination is inside the way of noticing synthetic cells.

Dynamic ParB–DNA interactions initiate and sustain a partition condensate for bacterial chromosome segregation

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Very great, but that wasn’t seriously where my curiosity lay. I planned cees dekker to pioneer And that i experienced the feeling that was not doable, because the most intriguing elementary insights experienced already been uncovered. But my area had formulated lots of thrilling new equipment to evaluate particular person molecules. I made a decision which i wanted to use this to biology, to take a look at it from the Bodily standpoint.’

Screening pseudotopological and nontopological products for SMC-driven DNA loop extrusion in opposition to roadblock-traversal experiments

‘That worries the artificial cell, as Section of the Dutch BaSyC initiative. Craig Venter appeared leading-down in All those times and recognized about 5 hundred genes which are minimally essential for a working cell. We wish to glimpse bottom-up: how do we go from the couple of molecules to a whole Organic procedure?

Visualization of unstained DNA nanostructures with Highly developed in-aim transmission electron microscopy methods

 Ultimately, I will briefly sketch a few of our Tips to check out the constructing of synthetic cells, particularly our very first measures to establish synthetic mobile division.